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A Systematic Review of the Risks of Stroke & Death Due to Endarterectomy for Symptomatic Carotid Stenosis
Stroke 27:260-265, Rothwell,P.M.,et al, 1996
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Article Abstract
Fifty-one studies fulfilled our criteria.Overall mortality was 1.62%(95% confidence 5 interval[CI],1.3 to 1.9),and the risk of stroke and/or death was 5.64%(95%CI,4.4 to 6.9).However,there was significant heterogeneity of risk of stroke and/or death(P<.001).The risk varied systematically with the methods and the authorship of the study.The risk of stroke and/or death was highest in studies in which patients were assessed by a neurologist after surgery(7.7%;95%CI,5.0 to 10.2)and lowest in studies with a single author affiliated with a department of surgery(2.3%;95%CI,1. 8 to 7.2).After correcting for study methodology,there was no temporal trend in the risk of stroke and/or death between 1980 and 1995.The reported risks of endarterectomy for symptomatic carotid stenosis show significantly greater variability than would be expected by chance. However,much of this variability can be accounted for by differences in methodology and authorship.The 5.6%overall risk of stroke and/or death is consistent with present guidelines.
 
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carotid artery disease
carotid artery stenosis
carotid artery stenosis,symptomatic
cerebrovascular accident
cerebrovascular accident,postoperative
endarterectomy,carotid
endarterectomy,carotid-complications of
endarterectomy,carotid-morbidity and mortality with
mortality
review article
risk factors

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